Justin Moscarello

Research Interests

• Neural pathways of learning and memory
• Active avoidance behavior and  aversively motivated action
• Disorders of emotional memory (PTSD)

The brain contains multiple memory systems. While these systems often work together, they can also compete to influence behavior. A frightening emotional memory can render you immobile, even if  you know from experience that action is needed to keep you safe. How does your brain resolve this conflict? What are the psychological and neurobiological mechanisms by which an adaptive balance is struck? What factors allow one form of memory to win out over another? These questions are the focus of study in the Moscarello Lab.

Active avoidance behavior is the primary model paradigm we use to explore conflict between different types of memory. This task requires the subject to resolve contrasting forms of learning in order to produce adaptive behavior. To understand this phenomenon, we conduct behavioral experiments informed by learning theory and combine this approach with cutting edge neuroscientific techniques (e.g. DREADDs, optogenetics, etc). Our goal is to illuminate the basic structure and function of memory systems in the mammalian brain, as well as to understand the implications of our data for clinical issues such as trauma, anxiety and resilience.

Affiliated Research Cluster

Neuroscience. Memory systems; psychological and neurobiological mechanisms of emotional memory; rodent models.
Affective Science. Control and fear; aversive memory.

Office Hours: Tues/Thurs 2-3PM

Accepting Students for 2024-2025?: Yes

Memberships: Institute for Neuroscience