Farida Sohrabji
  • Professor & Head of Department of Neuroscience and Experimental Therapeutics (Joint Appointment)

Research Interests

Selected Publications

    • Mani KK, El-Hakim Y, Branyan TE, Samiya N, Pandey S, Grimaldo MT, Habbal A, Wertz A, Sohrabji F (2023) Intestinal epithelial stem cell transplants as a novel therapy for cerebrovascular stroke. Brain, behavior, and immunity, 107:345-360
    • Sampath D, Branyan T. E., Markowsky K. G., Gunda R., Samiya N., Obenaus A., Sohrabji F. Sex differences in cognitive impairment after focal ischemia in middle-aged rats and the effect of iv miR-20a-3p treatment Neurobiol Aging 2023 Vol. 129 Pages 168-177
    • Bake S, Hurst DA, Miranda RC, Sohrabji F (2022) Prenatal alcohol exposure exacerbates acute sensorimotor deficits and impedes long-term behavioral recovery from the effects of an adult-onset cerebrovascular ischemic stroke. Alcoholism, clinical and experimental research, 46(12):2267-2279
    • Branyan TE, Selvamani A, Park MJ, Korula KE, Kosel KF, Srinivasan R, Sohrabji, F. (2021) Functional Assessment of Stroke-Induced Regulation of miR-20a-3p and Its Role as a Neuroprotectant. Translational Stroke Research. 2021. doi: 10.1007/s12975-021-00945-x
    • Bake, S., M. R. Pinson, S. Pandey, J. P. Chambers, R. Mota, A. E. Fairchild, R. C. Miranda and F. Sohrabji (2021). "Prenatal alcohol-induced sex differences in immune, metabolic and neurobehavioral outcomes in adult rats." Brain Behav Immun 98: 86-100
    • El-Hakim Y, Mani KK, Eldouh A, Pandey S, Grimaldo MT, Dabney A, et al. (2021)Sex differences in stroke outcome correspond to rapid and severe changes in gut permeability in adult Sprague-Dawley rats. Biology of Sex Differences, 12(1):1-16.
    • Panta A, Montgomery, K, Nicolas, Mani, K.K. Sampath D, Sohrabji, F (2020) Mir363-3p treatment attenuates delayed cognitive deficits precipitated by ischemic stroke in middle-aged female rats. Frontiers in Aging Neuroscience, doi: 10.3389/fnagi.2020.586362
    • Park M-J, Pilla R, Panta A, Pandey S, Sarawichitr B, Suchodolski J, Sohrabji F (2020). Reproductive Senescence and Ischemic Stroke Remodel the Gut Microbiome and Modulate the Effects of Estrogen Treatment in Female Rats. Transl Stroke Res, 11: 812–830
    • Bake S, Okoreeh A, Khosravian H, Sohrabji F (2019) Insulin-like Growth Factor (IGF)-1 treatment stabilizes the microvascular cytoskeleton under ischemic conditions. Experimental neurology 311:162-172
    • Panta A, Pandey S, Duncan IN, Duhamel S, Sohrabji F (2019) Mir363-3p attenuates post-stroke depressive-like behaviors in middle-aged female rats. Brain, Behavior, and Immunity. 1591(18)30489-6
    • Okoreeh AK, Bake S, Sohrabji F. (2017) Astrocyte-specific insulin-like growth factor-1 gene transfer in aging female rats improves stroke outcomes. Glia. 65:1043-1058. PMC5432389.
    • Park, M. J., & Sohrabji, F. (2016). The histone deacetylase inhibitor, sodium butyrate, exhibits neuroprotective effects for ischemic stroke in middle-aged female rats. J Neuroinflammation, 13(1), 300. doi:10.1186/s12974-016-0765-6
    • Selvamani A. and Sohrabji F. (2010) The neurotoxic effects of estrogen on ischemic stroke in older female rats is associated with age-dependent loss of IGF-1. J. Neurosci. 30: 6852-61. PMID: 20484627
    • Lewis DK, Bake S., Thomas K., Jezierski MK., Sohrabji, F. (2010) A high cholesterol diet elevates hippocampal cytokine expression in an age and estrogen-dependent manner in female rats. Journal of Neuroimmunology, 223:31-38, PMID: 20435353
    • Lewis DK, Thomas KT, Selvamani A, Sohrabji, F. (2012) Age-related severity of focal ischemia in female rats is associated with impaired astrocyte function. Neurobiol of Aging, 33:1123.e1-16. Epub 2011. PMID: 22154819
    • Selvamani A, Sathyan P, Miranda R.C. Sohrabji, F. (2012) An antagomir to microRNA Let7f promotes neuroprotection in an ischemic stroke model. PLoS ONE 7(2): e32662. PMID: 22393433
    • Balden R., Selvamani A., Sohrabji, F. (2012) Vitamin D deficiency exacerbates experimental stroke injury and dysregulates ischemia-induced inflammation in adult rats. Endocrinology, 153: 2420-35 PMID: 22408173
    • Sohrabji F, Selvamani A, Balden R. (2012) Revisiting the timing hypothesis: Biomarkers that define the therapeutic window of estrogen for stroke. Horm Behav. Jun 19. [Epub ahead of print] PMID: 22728278.
    • Sohrabji F, Williams M. Stroke neuroprotection: Estrogen and IGF-1 interactions and the role of microglia. J Neuroendocrinol. 2013 Jun 14. doi:10.1111/jne.12059. [Epub ahead of print] PubMed PMID: 23763366.
    • Sohrabji F, Bake S, Lewis DK. (2013) Age-related changes in brain support cells: Implications for stroke severity. Neurochem Int. 63: 291-301. Epub 2013 Jun 28. PubMed PMID: 23811611.
    • Selvamani A, Williams M, Miranda RC, Sohrabji F. (2014) Circulating miRNA profiles provide a biomarker for severity of stroke outcomes associated with age and sex in a rat model. Clin Sci, 127:77-89. PMID: 24428837
    • Bake S, Selvamani A, Cherry J. Sohrabji F. (2014) Blood Brain Barrier and Neuroinflammation Are Critical Targets of IGF-1-Mediated Neuroprotection in Stroke for Middle-Aged Female Rats. PLoS One, e91427.